CPN Trials

• Open and Active
  • MAY06-8-01 "Phase IIb Trial of Myo-inositol in Smokers with Bronchial Dysplasia"
  • MAY10-15-02 "Pioglitazone as a Candidate Chemoprevention Agent for Lung Cancer: A Pilot Trial Using a Pre-Surgical Model in Early Stage NSCLC"
  • MAY10-15-03 "Randomized Double Blind Placebo Controlled Phase II Trial of Barrett's Esophagus Chemoprevention with Metformin"
  • CPN0935 "Feasibility Study to Assess Interest for Chemoprevention Trial Participation Among BRCA Mutation Carriers"
  • CPN0942 "Pilot Study of MHC Class I Protein Expresson in FAP-Associated Dysplastic and Histologically-Normal Gastrointestinal Tissue Specimens"
  • CPN1033 "BRCA Gene Mutation Carrier Versus Normal Breast Tissue: Biomarkers of Breast Cancer Risk"
  • CPN1128 "Plasma and Sputum microRNAs: Utility as Noninvasive Biomarkers for the Progression/Regression of Bronchial Dysplasia"
  • CPN1145 "Effects of Atorvastatin on KRAS and BRAF Signaling Networks in Aberrant Crypt Foci (ACF)"
• In Development
  • MAY09-14-01 "Phase 0, Dose-Escalation Trial of SP-333 to Demonstrate Colorectal Bioactivity in Healthy Volunteers"
• Closed/Completed
  • MAY04-4-01 "Randomized, Double-Blinded Phase II Trial of Esomeprazole Versus Esomeprazole Plus Two Doses of Aspirin in Barrett's Esophagus Patients." The manuscript is in development.
  • MAY03-1-02 "Randomized Phase IIb Trial of Sulindac in Smokers With Bronchial Dysplasia." The manuscript is in development.
  • CPN1191 "Population-Based Pharmacokinetic Analyses of data from the Bioequivalency Study of Sulindac in Capsule vs. Tablet Formulations." This manuscript is in development.
  • MAY07-9-01 "Single-Dose Phase 0 Exploratory Pharmacokinetic Clinical Trial Comparing Five Oral Formulations of SR13668, an Orally Active AKT Pathway Inhibitor."
  • Review the published MAY07-9-01 manuscript.
  • MAY03-1-03 "Randomized Phase II Trial of Atorvastatin, Raftilose Synergy 1, and Sulindac Among Patients at Increased Risk for Sporadic Colorectal Neoplasia."
  • Review the published MAY03-1-03 manuscript.
  • MAY03-1-BIO "Bioequivalency Study of Sulindac in Capsule vs. Tablet Formulations."
  • Review the published MAY03-1-BIO manuscript.